About the Bioinformatics Centre
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Bioinformatics Centre at
JB Tropical Disease Research Centre, Mahatma Gandhi
Institute of Medical Sciences was established in March
1999 with support from Department of Biotechnology,
as part of National Bioinformatics Network. The Centre
has thrust on Medical / Health Informatics since inception
and is actively involved in infectious disease diagnostic
research and training. In addition to providing academic
bibliography service and in-house Training programme
for staff involved in Hospital Information service,
the Centre organizes yearly National level Workshop
/ Seminar / Symposium. So far 16 such events have been
organized which were well received and appreciated.
Further, this Centre also publishes SEVAMED a Quarterly
Update on Infectious Disease Research and Traditional
Medicine enters 15th year of its publication and has
been well received by the medical teachers and scientists
throughout India. In addition to giving selected references
and abstracts in hard copy ‘SEVAMED’ is
now available online with complete bibliography and
link to abstracts for easy retrieval with interactive
web pages, beneficial to the researchers, medical practitioners
and teachers. For more information, visit http://www.bicjbtdrc-mgims.in/ |
| Area
of Specialization: The Bioinformatics Centre
has thrust on Medical / Health Informatics |
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Objectives |
| (Besides, continuing with the
ongoing assignments, we wish to take up the new tasks
also) |
- Exploring Genome/Proteome analysis of M. tuberculosis
& HPV strains and databases development
- Quarterly updating SEVAMED publication, a quarterly
bibliography journal with thrust on infectious diseases
& lifestyle health problems
- Developing & updating web portal on advances
in research and health information on emerging infectious
diseases and lifestyle health problems
- Promoting education and human resource development
in Bioinformatics
- Establishing a moving academic platform for curriculum-based
training & research in Bioinformatics & Biotechnology
- Six monthly Online Health Informatics Certification
Course
- Organizing annual National Level Workshops on Biomedical
Informatics and Applied Tools & Techniques
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Achievements at a glance |
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Online Certificate
Course on Health Informatics (OHIC) |
| OHIC, six months certification
course is being conducted at Bioinformatics Centre, MGIMS,
Sevagram since July 2010 which provides online training
to Healthcare personnel and interested graduates in Science,
Business Administration & Information Technology and
33 students from UK, Uganda, Mauritius, Ethiopia, Saudi
Arabia and from different states of India have registered
so far. |
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SEVAMED….goes online
with complete bibliography and with link to abstracts |
| SEVAMED, a quarterly bibliography
journal with thrust on infectious diseases & lifestyle
health problems has entered 15th year of its publication.
This has been well received by the scientists & medical
teachers in medical colleges. Bioinformatics centre has
launched SEVAMED online as e-journal with complete bibliography
and with link to abstracts for easy retrieval with interactive
web pages. |
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Web Portals Developed |
| Centre has launched MGIMS-JBTDRC
Arogya Web Portal which presents progress being made in
Holistic Healthcare and Research in Lifestyle diseases
by Indian Institutions for better awareness, interaction
and advancement in holistic therapy and research (http://bicjbtdrc-mgims.in/arogya-webportal/).
This web portal basically provides healthcare information
at reputed Holistic Healthcare and Research Centers in
India on one platform for benefit of medical practitioners
and general public. |
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MGIMS-JBTDRC Health Update |
| MGIMS-JBTDRC Health Update
developed and quarterly updates are provided on emerging
infectious diseases and lifestyle health problems. |
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Database Developed |
| Centre has developed customized
Database Software for patients’ information and
further databases have been developed on Mycobacterial
proteases (Mycoprotease-DB, http://www.bicjbtdrc-mgims.in/MycoProtease-DB/),
Mycobacterium tuberculosis Proteome comparison (MTB-PCDB,
http://www.bicjbtdrc-mgims.in/MTB-PCDB/) and Human Papillomavirus
Proteome (hpvPDB, http://www.bicjbtdrc-mgims.in/hpvPDB/). |
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Workshops / Training Program
organized |
- National level workshops in Biomedical Informatics
and training courses in Infectious Diseases are organized
every year. So far 16 such events have been organized
which were well received and appreciated.
- Two sessions on curriculum-based training &
research in Bioinformatics, each for 6 days were conducted
in April and September, 2013 which was well appreciated.
Institutes running Bioinformatics and Biotechnology
courses have also requested to conduct such training
program in their Institute.
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Bioinformatics traineeship
and studentship |
| So far, 13 PG students have
completed their projects under Bioinformatics traineeship
and studentship programme. |
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Current areas of research |
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- Genome / Proteome analysis of M. tuberculosis &
HPV strains and databases development (Mycoprotease-DB,
MTB-PCDB and hpvPDB)
- Novel inhibitors against HPV through virtual screening
- TB proteome mutation analysis in different clinical
strains to understand drug resistance tuberculosis
- Exploring the effect of Isoniazid and Orlistat
inhibitors on Mtb ES-31 serine protease and other
enzymes of interest in TB by computational approach
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About the Institution
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| Bioinformatics
Centre at JB Tropical Disease Research Centre, Mahatma
Gandhi Institute of Medical Sciences was established in
March 1999 with support from Department of Biotechnology,
as part of National Bioinformatics Network. The Centre
has thrust on Medical / Health Informatics since inception
and is actively involved in infectious disease diagnostic
research and training. In addition to providing academic
bibliography service and in-house Training programme for
staff involved in Hospital Information service, the Centre
organizes yearly National level Workshop / Seminar / Symposium.
So far 16 such events have been organized which were well
received and appreciated. Further, this Centre also publishes
SEVAMED a Quarterly Update on Infectious Disease Research
and Traditional Medicine enters 15th year of its publication
and has been well received by the medical teachers and
scientists throughout India. In addition to giving selected
references and abstracts in hard copy ‘SEVAMED’
is now available online with complete bibliography and
link to abstracts for easy retrieval with interactive
web pages, beneficial to the researchers, medical practitioners
and teachers. For more information, visit http://www.bicjbtdrc-mgims.in/ |
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Databases / applications developed |
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| The following are the Databases
and Software for retrieval of information, comparison
and development of evidence based medicine for diagnosis,
management & research. |
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MTB - PCDB: Mycobacterium tuberculosis
Proteome Comparison Database |
| MTB-PCDB is an online database
with an integrated access to proteome sequence comparison
data on five strains of Mycobacterium tuberculosis (H37Rv,
H37Ra, CDC 1551, F11 and KZN 1435) sequenced completely
so far. Currently hosts 40252 protein sequence comparison
data. Proteome comparison data may be beneficial in discovery
& development of TB drugs, vaccines and biomarkers. |
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MycoProtease-DB a database
of M.tb and NTM proteases |
| MycoProtease-DB contains protease
information of Mycobacterium tuberculosis (MTB) complex
and Nontuberculous Mycobacteria (NTM) at gene, protein
and structural level whose complete genome sequence is
available. Currently hosts 1324 proteases, which include
906 proteases from MTB complex with 237 distinct proteases
& 418 from NTM with 404 distinct proteases. |
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HPV-PDB (Human papillomavirus
Proteome Database) |
| The Human papilloma Virus Proteome
Database (HPV-PDB) developed at this centre, domiciles
proteomic and genomic information on 150 HPV strains sequenced
so far. Easy expandability & retrieval of the strain
specific data at one place, facility for sequence analysis
& exploration potential of predicted structures, easy
access to curate and annotate data through various search
options etc are few of its important features. Data may
be helpful in exploring for designing the drugs and vaccines
against several such strains of HPV. |
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Inter Institutionnel collaboration |
| Exploring collaboration with
Dr. Varma Lab at Advanced Centre for Treatment, Research
and Education in Cancer (ACTREC), Mumbai for structural
& functional characterization of HPV strains |
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Infrastructure Facility |
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Bioinformatics
Centre at JBTDRC, MGIMS has been established in a carpet
area of around 240 sq feet accommodating Information
Officer, Technical Assistant, Two data entry operators
and a computer operator. Coordinator and Dy coordinator
have separate chambers with a few units installed and
a scope for further expansion incase required.
Computer & Communication facility:
i. Computer Hardware: (i) Server –
3, (ii) Dell Workstations - 4 (iii) PCs - 19; (iv) Laptop
- 3; (v) Printers - 4, (vi) Photocopier, digital copier
cum printer - 4 (vii) Cisco Router, (viii) Patton Modem,
(ix) Wireless router-2, (x) Switches, (xi) LCD Projector
(3), (xii) Scanner, (xiii) Digital Camera, (xiv) Sony
Handy cam. (xv) Spiral Binder etc.
Bioinformatics Centre, Immunology & Molecular Biology
laboratories are networked through LAN.
ii. Computer Software: Windows NT with
service pack 6, Microsoft Windows NT 4.0 Service pack
4, Windows 98, 2000, XP, Office 2007, SQL Svr Standard
Edtn 2005 Win 32, Visual Studio Pro 2008, Visio Std
2007, Developer Training Service Pack 3, Microsoft Visual
Studio 6.0 Professional Edition with MSDN Library, Adobe
Dreamweaver CS3 Win 9.0, Flash Pro CS3 Win 9.0, Adobe
Photoshop Extended CS3 10.0, Win Adobe PageMaker 6.5,
Wings 2000, Tally 7.2. MATLAB 7, Geneious Pro &
freely available online Bioinformatics software for
sequence analysis, 3D visualization tools etc. are also
being used.
iii. Communication Facility: The Institute
has got installed 1 Gbps Internet connectivity and campus
is Wi-Fi with high bandwidth.
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Recent
Publications |
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Lingaraja Jena, Supriya Kashikar, Satish Kumar,
Bhaskar C. Harinath. Comparative proteomic analysis
of Mycobacterium tuberculosis strain H37Rv versus
H37Ra. International Journal of Mycobacteriology
2(4): 220 - 226 (2013). |
Satish Kumar, Lingaraja Jena, Sangeeta Daf,
Kanchan Mohod, Peyush Goyal, Ashok K. Varma. hpvPDB:
An Online Proteome Reserve for Human Papillomavirus.
Genomics & Informatics 11(4): 1-3 (2013). |
Kumar S, Jena L, Mohod K, Daf S, Varma A.,
In silico inhibitors for human papillomavirus
16 E7 protein, Onl J Bioinform., 14 (3): 302-310,
2013. |
Satish Kumar, Lingaraja Jena, Vidya W. Bhomale
& Sangeeta Daf. In silico Structural Prediction
of E6 and E7 Proteins of Human papillomavirus
Strains by Comparative Modeling. International
J Bioautomation, 2012;16(2):101-110 |
Lingaraja Jena, Satish Kumar, Bhaskar Chinnaiah
Harinath. MycoProtease-DB: Useful resource for
Mycobacterium tuberculosis complex and nontuberculous
mycobacterial proteases. Bioinformation 8(24):
1240-1242 (2012) |
| Lingaraja Jena, Gauri Wankhade, Satish
Kumar, Bhaskar Chinnaiah Harinath. MTB-PCDB: Mycobacterium
tuberculosis proteome comparison database. Bioinformation
2011;6(3):131-133. |
| Deshmukh P, Jumde J, Kumar S, Reddy MVR, Harinath
BC. FilaDB - Database software for information storage
and retrieval on detection and management of filaria
patients. Bioinformatics India. Oct-Dec 2005;3(4):36-46. |
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Faculty Members |
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Dr. B.C. Harinath, PhD.
Director, JBTDRC
Coordinator, BIC & Arogyadham
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Dr. Satish Kumar, MD
Professor, Biochemistry &
Dy Coordinator, BIC
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Mr. Lingaraja Jena
Information Officer, BIC
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| Contacts: |
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Bioinformatics centre
JB Tropical Disease Research Centre
Mahatma Gandhi Institute of Medical Sciences, Sevagram
(Wardha) – 442102, Maharashtra. India
Tele Fax: 07152 – 284038
E-mail: mgims.btisnet@nic.in, info@jbtdrc.org
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| Coordinator: |
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Dr. B.C. Harinath,
PhD.
Director, JBTDRC |
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