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HOLY CROSS COLLEGE, TRICHY


About the Bioinformatics Centre
 

 

The Bioinformatics centre at Holy Cross College was established in 2006 with financial support from Government of India, Ministry of Science and Technology, Department of Biotechnology (DBT), New Delhi. The Centre offers M.Sc Bioinformatics & PG Diploma in Bioinformatics Courses from its inception in addition to M.Sc, M.Phil and Ph.D Programs in Biotechnology. Since its inception, the main attention of the Centre is to set up strong bioinformatics programs that have started generating high impact publications and development of manpower in the area of Bioinformatics. The Centre offers computational facilities to the users from the nearing Institutions and Universities. The centre has emerged and elevated as an outstanding Bioinformatics centre in this region and will continue to contribute significantly in the development of manpower.

 

Area of specialization:

  • Phytochemistry of Medicinal Plants
  • Hypoglycemic, Anitmicrobial , Antioxidant , Anti-inflammatory, Anticancerous and     Immunomodulatroy activities of phytocontituents of Medicinal Plants
  • Protein & Genome Expression Analysis
  • In- Silico Drug Designing
  • Cell based assays.
 
Objectives
  • To provide a platform for young minds to diverge and evolve profoundly in the arenas of Bioinformatics.
  • To promote Human resource development in the areas of Bioinformatics by conducting Training programme.
 
Current area of research

Software development

Identification of a particular target and pharmacokinetic property for a ligand is a tedious process involving high cost and time. Cancer is a complex disease comprising of a number of signaling molecules in action, making the exploration of targeted drug action, a complex process. Hence, the DBT-BIF Centre of Holy Cross College is working on developing software that is built up with pharmacokinetic informations of various cancer markers and several generalized signaling pathways involved. This stands as a key area of research ongoing in the centre that would support in predicting the targeted activity of a drug in a short period of time.

 

Phytodrugs for Cancera

Cancer is the most dreadful diseases causes by the abnormal growth of cells in the body. In many countries cancer is the second leading cause of death after heart diseases. Because of the high death rate associated with cancer and because of serious side effects of chemotherapy and radiation therapy, many cancers patients seek alternative or complementary methods of treatment. This in turn justifies the interest in search of possible anticancer agents from the plants. In the light of this, the BIF centre of Holy Cross College is searching for lead molecules in plants through in silicoin vitro and in vivo approaches. Research scholars of the department are on their way to achieve this objective.

 

Screening of DNA binding blockers against Staphylococcus aureus

Antibiotic resistance is one of the most serious health threats threatening all over the world. Staphylococcus aureus is the most common bacteria showing resistance to various antibiotics In concurrent to these, discovery of novel drug for antibiotic resistance attains more interest. The centre has involved in searching inhibitors targeting DNA of Staphylococcus aureus. The centre has already screened several chemical compounds by using various bioinformatic analysis like pharamacophore mapping, Qm/MM docking etc.

 

Medicinal herbs for Diabetes

Diabetes mellitus (DM) is a non-communicable disease, which is considered one of the five leading causes of death in the world. About 150 million people suffer from diabetes worldwide, which is almost five times more than the estimates ten years ago and this may be doubled by the year 2030. Diabetes mellitus results when there is an inadequate functional mass of pancreatic β cells.Islets of Langerhans, irregularly shaped patches of endocrine tissue located within the pancreas of most vertebrates. The most common islet cell, beta cell, produces insulin, the major hormone in the regulation of carbohydrates, fat, and protein metabolism. In type 1 diabetes, immune-mediated destruction of β cells leaves a markedly reduced β cell mass. Currently, the centre focuses on the various approaches to identify the mode of beta cell regeneration aided by the phytocompounds through in silico and in vivo approaches.

Databases/applications developed

Inter Institutionnel collaboration

International collaborators

  • Dr.Thameem Dheen, National University of Singapore. Singapore
  • Dr. Antonietta La.Terza, University of Camerino. Italy.
  • Dr.Arun Dharmarajan, School of Anatomy and Physiology, Western University of Australia.
  • Dr.Shakila.K.Banu, Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A& M University, TX, USA, for the promotion of Research and Advancement.
  • Dr.G. Agaramoorthy, Tajen University, Taiwan.
 

National Collaborators

  • Dr.Sanjeev Kumar Singh, Associate Professor Department of Bioinformatics, Alagappa university, Karaikudi.
  • Dr.D.Velmurugan, Head, Center for Advanced Study in Crystallography and Biophysics, University of Madras, Chennai.
  • Dr.R.Rajashekaran, Assistant professor, Bioinformatics Division, VIT, Vellore.
  • Dr. S. Karutha Pandian, Professor & Head, Department of Biotechnology,
    Alagappa University, Karaikudi
  • Dr.K.Balasubramanian, Professor, Department of Endocrinology, Dr.A.L.M.P.G.I.B.M.S, University of Madras, Chennai.
  • Dr.J.Arunakaran, Associate professor Department of Endocrinology, Dr.A.L.M.P.G.I.B.M.S, University of Madras, Chennai.
  • Rev.Fr.Ignacimuthu, Department of Botany, Loyola College, Chennai.
 
Achievements at a glance

Workshops Organized – 18
Paper Published – 80
Books Published - 2
Patents:
Patents granted

  • Patent No.:244666; Journal No. 51/2010

Title of the invention : A process for preparation of a novel compound, 5,6-dihydroxy-3-[(4-hydroxy-6(hydroxymethyl)-3,5-DI[3,4,5-trihydroxy-6-(hydroxymethyl) tetrahydro-2H-2pyranyl] oxytetrahydro-2H-2-pyranyl)oxy] -2-methoxy-10, 13- imethylperhydrocyclopenta [α] phenanthren-17-yl (phenyl)methylacetate from Syzygium cumini  skeels, seeds with antibacterial and antidiabetic activity.

  • Patent No.:246537 -2011

Title of the invention:A process for preparation of a novel compound Gymnemic triacetate from Gymnema sylvestre R. BR.leaves with antidiabetic activity

Patents Filed:

  • Terpenoid from Elephantopus scaber
  • Dihydroxy G triacetate and G diacetate from Gymnema sylvestre
  • 17-[(E)-4-ethyl-1’,5’-dimethyl-2’-hexenyl]-11-hydroxy-5-(hydroxymethyl)-13,14-dimethyl-5,6,7,11,12,13,14,15,16,17-decahydro-3H-cyclopenta[a]phenanthren-3-one from Cassia fistula
  • 17-[(E)-1’,5’-dimethyl-2’-hexenyl]-11-hydroxy-5-(hydroxymethyl)-13,14-dimethyl-5,6,7,11,12,13,14,  15,16,17-decahydro-3H-cyclopenta[a]phenanthren-3-one from Cassia fistula
  • 17-[(2E,5E)-4’,7’-diethyl-1’,8’-dimethyl-2’,5’-nonadienyl]-11-hydroxy-5-(hydroxymethyl)-13,14-dimethyl-5,6,7,11,12, 13,14, 15, 16,17-decahydro-3H-cyclopenta[a]phenanthren-3-one from Cassia fistula


About the Institution
 

Holy Cross College is one of the oldest colleges for women in South India.  It is affiliated to Bharathidasan University and it is run by the Sisters of the Cross of Chavanod, Province of Tiruchirappalli. The College made its genesis in 1923, and in 1987 it was commissioned to function as an autonomous college, being affiliated to the Bharathidasan university.The College was accredited by NAAC (National Assessment and Accreditation Council) in 1999 with FIVE STARS and was Reaccredited by NAAC in 2012 (Third Cycle) with  A Grade.  It was recognised by UGC as a College with Potential for Excellence (CPE) in 2012. The college is funded by DBT-Star college scheme supporting all the life science departments.

 
Databases/applications developed

DIAB 1&2

          The database provides basic information on medicinal plants having antidiabetic, antimicrobial, antioxidative and anti cancer effects. The database includes botanical, toxicological, biochemical as well as pharmacological properties of medicinal plants.
 
Infrastructure facilities
The centre has one HP server with Microsoft Windows and 30 personal computers with Local Area Networking facility. The Centre has been successfully providing continuous up-to date information and access to software and databases.  The centre is equipped with various Commercial and non commercial software packages like Accelrys Discovery Studio, Auto dock, Argus Lab, Hex, Modeller9V11, Phylip, Mega,  Accord Excel, Geneious, GROMACS, Geno Cluster .
 
Recent publications

 

Daisy P (2013). Therapeutic potential of octyl gallate isolated from fruits of Terminalia bellerica in streptozotocin-induced diabetic rats. Pharmaceutical Biology Biol. 51(6):798-805 (Impact factor-1.206).

Pitchai Daisy, Periyasamy Vijayalakshmi, Chandrabose Selvaraj, Sanjeev Kumar Singh., Kandasamy Saipriya., (2013). Targeting Multidrug Resistant Mycobacterium tuberculosis HtrA2 with Identical Chemical Entities of Fluoroquinolones. Indian Journal Of Pharmaceutical Sciences. 74(3):217-222 (Impact Factor: 0.67).
P Daisy, FGJ Kani (2013). Hypolipidemic and hepatoprotective effects of cassia auriculata linn bark extracts on streptozotocin induced diabetics in male wister albino rats. Asian Journal of Pharmaceutical & Clinical Research . 6(2):43-48 Impact factor 1.1117.

Pitchai Daisy, Rajamanickam Pon Nivedha, Rajamanickam Helen Bakiya, (2013). In-silico drug designing approach for biotin protein ligase of Mycobacterium tuberculosis. Asian Journal of Pharmaceutical and Clinical Research. 6(1):103-107 Impact factor. 0.7.

Periyasamy Vijayalakshmi, Chandrabose Selvaraj, Sanjeev Kumar Singh, Jaganathan Nisha, Kandasamy Saipriya & Pitchai Daisy.(2012). Exploration of the binding of DNA binding ligands to Staphylococcal DNA through QM/MM docking and molecular dynamics simulation. Journal of Biomolecular Structure and Dynamics. DOI: 10.1080/07391102.2012.706080., 1-11. Impact Factor-4.99.

P.Daisy, S Suveena (2012). Solutions to pharmaceutical issues for anti-cancer drugs by accord excel. Asian Journal of Pharmaceutical & Clinical Research 5 (3) (Impact factor-0.7).

P.Daisy, FGJ Kani. (2012). Evaluation of Antidiabetic activity of various extracts of Cassia Auriculata Linn. Bark on Streptozotocin-induced diabetic Wistar Rats International Journal of Pharmacy and Pharmaceutical Sciences 4 (4), 312-318 (Impact factor: 0.2)
Arunkumar.R, Sharmila.G, Elumalai.P, Senthilkumar.K, Banudevi.S, Gunadharini. D.N,  Benson,C.S, Daisy.P, Arunakaran.J., (2012). Effect of diallyl disulfide on insulin-like growth factor signaling molecules involved in cell survival and proliferation of human prostate cancer cells in vitro and in-silico approach through docking analysis. Phytomedicine. 19(10):912-23. Impact factor 3.268.

SreeVishupriya K, Chandrsekaran P, Senthilkumar A,  Sethumadhavan R, Shanthi V, Daisy.P,  Nisha J,  Ramanathan K & Rajasekaran R., (2012).  Computational analysis of deleterious missense mutations in aspartoacylase that cause Canavan’s disease. Journal of  Science China Life Sciences. 55:1109-1119. (Impact Factor : 2.02).

Daisy.P., Saipriya.K., (2012). A Comparative study on Biochemical analysis of Cassia fistula aqueous extract and phytochemically synthesized gold nanoparticles as Hypoglycemic agents in the treatment of Diabetes mellitus. International Journal of Nanomedicine. 2012:7 1189–1202. Impact Factor-4.976.

Daisy Pitchai., Suveena. S., (2012).  Solutions to pharmaceutical issues for anti-cancer drugs by accord excel. Asian Journal of Pharmaceutical and Clinical Research. 5(3): 149-158. Impact factor: 0.7.

Daisy Pitchai., Suveena. S., (2012). Target level analysis of antioxidant activity of costunolide and eremanthin isolated from Costus speciosus. Asian Journal of Pharmaceutical and Clinical Research. 5(4): 32-35. Impact factor: 0.7.

Daisy Pitchai, Vijayalakshmi Gopalakrishnan, Vijayalakshmi Periyasamy and Rajalakshmi Manikkam.,(2012). In-Silico modeling and docking studies of AA2BR with catechin to explore the anti diabetic activity. International Journal of pharmacy and pharmaceutical sciences. 4(3), 328-333. Impact: 0.38.

Daisy Pitchai, Lizzy Jaculine, Rajalakshmi Manikkam., (2012). Identification of dual agonistic novel ligands for insulin receptor and PPARγ through molecular docking. International Journal of Pharmacy and Pharmaceutical Sciences. 4(4):142-147 Impact Factor-0.38.

P. Daisy, Feril G. Jeeva Kani, (2012).  Evaluation of antidiabetic activity of various extracts of Cassia auriculata linn. Bark on streptozotocin- induced diabetic Wistar rats. International Journal of Pharmacy and Pharmaceutical Sciences. 4(4), 312-318. Impact Factor-0.38.

Daisy Pitchai, Rajalakshmi Manikkam., (2012). Hypolidemic, hepato-protective and renal damage recovering effects of catechin isolated from the methanolic extract of Cassia fistula stem bark in Steptozotocin- induced diabetic Wistar rats: a biochemical and morphological analysis. Medicinal Chemistry Research. Doi.10.1007/s00044-012-9989x. Impact Factor-1.037.

 
 
Faculty members

Name

Designation

Dr. P. Daisy,

Head & Associate Professor in Zoology and Co-ordinator

Dr. M. Rajalakshmi

Assistant Professor in Zoology and Part-Time Research Assistant.

Ms.P.Vijayalakshmi,

Research Assistant

Ms.R.Pon Nivedha

Trainee

Ms.A.Ludas

Studentship

 
 
 

Contacts

Postal Address: Dr.P. Daisy, Co-ordinator
Head & Associate Professor of Zoology, Biotechnology & Bioinformatics Infrastructure Facility, Holy Cross College (Autonomous),
Tiruchirappalli-02

Email id: daisylesslie@gmail.com
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